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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC6
All Species:
22.42
Human Site:
S449
Identified Species:
37.95
UniProt:
Q99741
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99741
NP_001245.1
560
62720
S449
D
G
N
R
M
T
L
S
Q
E
G
A
Q
D
S
Chimpanzee
Pan troglodytes
XP_001170406
560
62717
S449
D
G
N
R
M
T
L
S
Q
E
G
A
Q
D
S
Rhesus Macaque
Macaca mulatta
XP_001096756
559
62520
L448
V
D
G
N
R
M
T
L
S
Q
G
A
Q
D
S
Dog
Lupus familis
XP_537648
559
62507
S448
D
G
N
R
M
T
L
S
K
E
G
A
Q
D
S
Cat
Felis silvestris
Mouse
Mus musculus
O89033
562
62595
S451
D
G
N
R
V
T
L
S
Q
E
N
T
Q
D
S
Rat
Rattus norvegicus
NP_001101768
561
62295
S450
D
G
N
R
V
T
L
S
Q
E
N
T
Q
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519126
361
39672
T265
K
G
Q
D
V
L
Y
T
L
F
E
W
P
W
L
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001081844
554
60731
S444
V
Y
G
D
K
M
A
S
N
G
G
S
S
D
S
Zebra Danio
Brachydanio rerio
NP_001120805
561
61262
S450
V
Y
G
D
R
M
A
S
S
S
G
D
G
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648247
662
75116
L548
V
Y
G
A
S
Q
N
L
E
E
D
I
E
A
S
Honey Bee
Apis mellifera
XP_625142
549
62089
N437
G
V
Y
G
G
S
Q
N
I
E
K
E
E
N
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999666
582
64455
S461
Y
G
S
G
V
M
T
S
A
G
G
K
G
Q
S
Poplar Tree
Populus trichocarpa
XP_002299817
498
55546
Q402
D
T
I
Q
S
L
P
Q
H
Q
Q
M
I
L
C
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09119
513
58018
I417
L
N
I
Q
Q
K
L
I
L
C
T
I
I
Q
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96
89.1
N.A.
79.5
80
N.A.
45.3
N.A.
63.7
49
N.A.
33.9
36
N.A.
40
Protein Similarity:
100
100
97.5
93.5
N.A.
87.3
88.9
N.A.
52.8
N.A.
77.5
67.3
N.A.
52.1
57.3
N.A.
58.5
P-Site Identity:
100
100
33.3
93.3
N.A.
80
80
N.A.
6.6
N.A.
26.6
20
N.A.
13.3
6.6
N.A.
26.6
P-Site Similarity:
100
100
40
100
N.A.
86.6
86.6
N.A.
20
N.A.
33.3
26.6
N.A.
26.6
40
N.A.
40
Percent
Protein Identity:
25.8
N.A.
N.A.
N.A.
20.1
N.A.
Protein Similarity:
46.4
N.A.
N.A.
N.A.
41.2
N.A.
P-Site Identity:
6.6
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
15
0
8
0
0
29
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% C
% Asp:
43
8
0
22
0
0
0
0
0
0
8
8
0
50
0
% D
% Glu:
0
0
0
0
0
0
0
0
8
50
8
8
15
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
8
50
29
15
8
0
0
0
0
15
50
0
15
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
15
0
0
0
0
8
8
0
0
15
15
0
0
% I
% Lys:
8
0
0
0
8
8
0
0
8
0
8
8
0
0
0
% K
% Leu:
8
0
0
0
0
15
43
15
15
0
0
0
0
8
8
% L
% Met:
0
0
0
0
22
29
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
8
36
8
0
0
8
8
8
0
15
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% P
% Gln:
0
0
8
15
8
8
8
8
29
15
8
0
43
15
0
% Q
% Arg:
0
0
0
36
15
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
8
0
15
8
0
58
15
8
0
8
8
0
79
% S
% Thr:
0
8
0
0
0
36
15
8
0
0
8
15
0
0
8
% T
% Val:
29
8
0
0
29
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% W
% Tyr:
8
22
8
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _